Anti-Aging Peptides

Anti-Aging Peptides

Peptides are short chains of amino acids that are a vital research tool for improving specific biological processes that occur naturally within the body. Peptides can be used to develop targeted therapies by interacting with specific receptors or enzymes. In cosmetics, peptides are often employed for their ability to promote skin regeneration, reduce wrinkles, and enhance hydration by stimulating collagen production. Their versatility make them powerful ally for advancing both medical treatments and cosmetic enhancements.

NAD+

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme that focuses on DNA and cellular repair slowing down the aging process, supporting brain health and mental clarity, improving sleep, reducing depression, lowering stress and boosting energy.

  • Energy Metabolism: This peptide is essential for converting nutrients into cellular energy (ATP) through metabolic pathways.
  • Sirtuin Activation: This peptide activates sirtuins, a family of proteins that regulate metabolic health, stress resistance, and longevity.
  • Cellular Signaling: This peptide is involved in cell signaling pathways that regulate essential functions like inflammation, cell survival, and circadian rhythms.
  • DNA Repair: This peptide is a key player in maintaining genomic stability by facilitating DNA repair mechanisms, protecting cells from damage and mutations.


Key Research Areas for NAD+:

  • Metabolic Disorders: NAD+ plays a critical role in metabolic health. Research investigates its impact on conditions like obesity, diabetes, and metabolic syndrome. By enhancing NAD+ levels, scientists aim to improve metabolic function and address the root causes of these disorders.
  • Aging and Longevity: NAD+ levels naturally decline with age, contributing to the aging process and age-related diseases. Research has shown that replenishing NAD+ can improve cellular function, promote healthy aging, and potentially extend lifespan. Studies focus on understanding how NAD+ influences age-related decline and developing strategies to maintain or restore NAD+ levels in aging populations.
  • Cardiovascular Health: NAD+ is vital for maintaining cardiovascular health. Research explores its role in protecting the heart, improving blood vessel function, and reducing the risk of cardiovascular diseases. Increasing NAD+ levels may offer new therapeutic approaches for heart health.
  • Neurodegenerative Diseases: Neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease are linked to impaired cellular energy metabolism and oxidative stress. NAD+ supplementation is being studied for its potential to support brain health, improve cognitive function, and protect against neurodegeneration.
  • DNA Repair and Cancer: NAD+ is crucial for DNA repair mechanisms. Research is focused on how enhancing NAD+ levels can improve DNA repair capacity, protect against mutations, and potentially reduce cancer risk. Understanding NAD+’s role in genomic stability is key to developing novel cancer therapies.


GHK-Cu

GHK-Cu is a naturally occurring peptide found in human blood, urine, and saliva that promotes wound healing, immune function, and skin health. Its ability to stimulate collagen and fibroblast activity, promote blood vessel growth, and act as an antioxidant, makes it a powerful ally in anti-aging treatments and skin rejuvenation.

Key Research Benefits of GHK-CU

  • Enhanced Wound Healing: GHK-CU has demonstrated remarkable efficacy in accelerating wound healing. By stimulating collagen production and promoting the activity of fibroblasts, GHK-CU enhances tissue repair and regeneration. This peptide’s ability to improve blood vessel growth further supports its role in optimizing the wound healing process, making it indispensable for studies in regenerative medicine.
  • Immune Function Support: Research indicates that GHK-CU plays a crucial role in modulating immune function. Its presence in the body acts as a feedback signal following tissue injury, initiating processes that promote healing and recovery. By enhancing immune response, GHK-CU contributes to improved health outcomes, providing a valuable avenue for exploring immune-related therapies.
  • Skin Health and Anti-Aging: GHK-CU’s impact on skin health is profound. It stimulates collagen synthesis, which is essential for maintaining skin elasticity and firmness. Additionally, its antioxidant properties help suppress free-radical damage, offering protection against oxidative stress. These qualities make GHK-CU a potent agent in anti-aging research, with potential applications in skincare and cosmetic formulations.


BPC-157

BPC-157 is a synthetic peptide derived from a protein found in human gastric juice. It has gained interest in preclinical research for its tissue repairing, anti-inflammatory, and protective effects, primarily in muscle, tendon, nerve, and gastrointestinal studies.


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Key Research Benefits of BPC-157

  • Accelerated Tissue Healing: Promotes faster healing of muscles, tendons, ligaments, and bones. May enhance recovery from musculoskeletal in juries like tendon ruptures and muscle tears.
  • Gastrointestinal Protection: Shown to heal gastric ulcers, leaky gut, and intestional inflammation. Protects the mucosal lining of the GI tract, even under NSAID-induced stress.
  • Neuroprotective Effects: May support nerve regeneration and reduce damage after traumatic brain injury or peripheral nerve injury.
  • Anti-Inflammatory Action: Reduces systemic and local inflammation, possibly by modulating nitric oxide pathways and cytokine activity.
  • Vascular and Endothelial Healing: Improves blood vessel growth and repair, which may benefit wound healing and ischemic injuries.
  • Organ Protection and Regeneration: In preclinical studies, BPC-157 showed protective effects in liver, pancreas, kidneys, and heart against various forms of injury or toxicity.



AOD 9604

AOD 9604 is a peptide fragment derived from the human growth hormone (specifically the C-terminus, amino acids 176–191), and has been studied primarily for its potential fat-reducing properties without the side effects associated with full-length growth hormone.


Key Research Benefits of AOD 9604

  • Fat Metabolism Enhancement: AOD has been shown to stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (formation of new fat), particularly in abdominal adipose tissue, potentially making it useful in obesity-related research.​​​​
  • Non-Impact on Blood Sugar or Insulin: Unlike human growth hormone, AOD does not affect blood glucose or insulin levels, making it a safer candidate in metabolic studies.
  • No IGF-1 Stimulation: It does not increase insulin-like growth factor 1 (IGF-1), reducing the risk of side effects like abnormal tissue growth often associated with full GH therapy.
  • Potential Anti-Inflammatory Effects: Some studies suggest AOD may help reduce inflammation, which could make it useful in research related to arthritis, injury recovery, or chronic inflammation.


Selank

Selank is a synthetic peptide based on a natural human tetrapeptide called tuftsin, which is involved in immune regulation. It has been studied primarily for its nootropic, anxiolytic, and immune-modulating properties.


Key Research Benefits of Selank

  • Anxiolytic (Anti-Anxiety) Effects: Selank has shown significant anxiety-reducing effects in preclinical and clinical studies, comparable to benzodiazepines but witout sedation, addiction, or withdrawl symptoms.
  • Cognitive Enhancement: Research indicates improved memory, focus, and learning. It may enhance neuroplasticity and protect against stress-induced cognitive decline.
  • Mood Stabilization: Modulates serotonin and dopamine levels, contributing to potential benefits in depression and mood disorders.
  • Immune System Modulation: Enhances immune response by regulating interferons and other cytokines, showing potential in viral infections and immune-compromised states.
  • Stress Reduction: Normalizes behavior and biochemical markers in chronic stress models, possibly by stabilizing brain-derived neurotrophic factor (BDNF) levels and reducing oxidative stress.
  • Improved Attention and Alertness: In studies involving individuals with attention deficits or anxiety, Selank improved mental clarity and alterness without overstimulation.


Sermorelin

Sermorelin is a synthetic peptide that mimics growth hormone-releasing hormone (GHRH), stimulating the pituitary to produce more endogenous growth hormone (GH). While approved clinically for growth hormone deficiency in children, most current uses are for research purposes.

Key Research Benefits of Sermorelin

  • Stimulates Natural GH Production: Encourages the body's own GH release, supporting a more physiologic and regulated hormone profile compared to exogenous GH.
  • Supports Muscle Growth and Fat Reduction: Studies suggest it may enhance lean body mass and reduce adipose tissue, particulary visceral fat, by boosting IGF-1 levels.
  • Improves Sleep Quality: May increase slow-wave (deep) sleep, a phase associated with natural GH pulses, aiding in recovery and cognitive function.
  • Anti-Aging and Cellular Repair Potential: Research indicates Sermorelin may help with skin elasticity, wound healing, and collagen synthesis, making it a target in longevity studies.
  • Bone Density Support: By increasing GH/IGF-1 levels, it may enhance osteoblast activity and support bone mineral density, particularly in aging models.
  • ​​​​​​​​​​​​​​​​​​Enhanced Recovery and Physical Performance: Investigational use shows possible faster recovery from injuries and improved stamina, especially in aging or GH-deficient models.
  • Neuroprotective Effects: Some preclinical research suggests GH-releasing peptides like Sermorelin may have cognitive and neuroprotective effects, though data is limited.




Some peptides are research chemicals and not approved by the FDA.